6B8F

Contracted Human Heavy-Chain Ferritin Crystal-Hydrogel Hybrid

6B8F の概要

• エントリーDOI: 10.2210/pdb6b8f/pdb
• 分子名称: Ferritin heavy chain, FE (III) ION, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, hydrogel, polymer
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21637.80

構造登録者

Zhang, L.,Bailey, J.B.,Subramanian, R.,Tezcan, F.A. (登録日: 2017-10-07, 公開日: 2018-05-02, 最終更新日: 2024-03-13)

主引用文献

Zhang, L.,Bailey, J.B.,Subramanian, R.H.,Tezcan, F.A.
Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks.
Nature, 557:86-91, 2018

PubMed Abstract: The formation of condensed matter typically involves a trade-off between structural order and flexibility. As the extent and directionality of interactions between atomic or molecular components increase, materials generally become more ordered but less compliant, and vice versa. Nevertheless, high levels of structural order and flexibility are not necessarily mutually exclusive; there are many biological (such as microtubules, flagella , viruses) and synthetic assemblies (for example, dynamic molecular crystals and frameworks) that can undergo considerable structural transformations without losing their crystalline order and that have remarkable mechanical properties that are useful in diverse applications, such as selective sorption , separation , sensing and mechanoactuation . However, the extent of structural changes and the elasticity of such flexible crystals are constrained by the necessity to maintain a continuous network of bonding interactions between the constituents of the lattice. Consequently, even the most dynamic porous materials tend to be brittle and isolated as microcrystalline powders , whereas flexible organic or inorganic molecular crystals cannot expand without fracturing. Owing to their rigidity, crystalline materials rarely display self-healing behaviour . Here we report that macromolecular ferritin crystals with integrated hydrogel polymers can isotropically expand to 180 per cent of their original dimensions and more than 500 per cent of their original volume while retaining periodic order and faceted Wulff morphologies. Even after the separation of neighbouring ferritin molecules by 50 ångströms upon lattice expansion, specific molecular contacts between them can be reformed upon lattice contraction, resulting in the recovery of atomic-level periodicity and the highest-resolution ferritin structure reported so far. Dynamic bonding interactions between the hydrogel network and the ferritin molecules endow the crystals with the ability to resist fragmentation and self-heal efficiently, whereas the chemical tailorability of the ferritin molecules enables the creation of chemically and mechanically differentiated domains within single crystals.

PubMed: 29720635
DOI: 10.1038/s41586-018-0057-7

実験手法

X-RAY DIFFRACTION (1.06 Å)