6B6E

Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 500ms

Summary for 6B6E

Related6b6b 6b6c 6b6d
DescriptorBeta-lactamase, (2R)-2-[(1S)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-hydroxyethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Ceftriaxone, ... (4 entities in total)
Functional Keywordsbeta-lactamase, antibiotic, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains1
Total molecular weight29354.88
Authors
Pandey, S.,Schmidt, M. (deposition date: 2017-10-01, release date: 2018-06-27)
Primary citation
Olmos, J.L.,Pandey, S.,Martin-Garcia, J.M.,Calvey, G.,Katz, A.,Knoska, J.,Kupitz, C.,Hunter, M.S.,Liang, M.,Oberthuer, D.,Yefanov, O.,Wiedorn, M.,Heyman, M.,Holl, M.,Pande, K.,Barty, A.,Miller, M.D.,Stern, S.,Roy-Chowdhury, S.,Coe, J.,Nagaratnam, N.,Zook, J.,Verburgt, J.,Norwood, T.,Poudyal, I.,Xu, D.,Koglin, J.,Seaberg, M.H.,Zhao, Y.,Bajt, S.,Grant, T.,Mariani, V.,Nelson, G.,Subramanian, G.,Bae, E.,Fromme, R.,Fung, R.,Schwander, P.,Frank, M.,White, T.A.,Weierstall, U.,Zatsepin, N.,Spence, J.,Fromme, P.,Chapman, H.N.,Pollack, L.,Tremblay, L.,Ourmazd, A.,Phillips, G.N.,Schmidt, M.
Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
BMC Biol., 16:59-59, 2018
PubMed: 29848358 (PDB entries with the same primary citation)
DOI: 10.1186/s12915-018-0524-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.901 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.245170.4%0.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution