6B5V

Structure of TRPV5 in complex with econazole

6B5V の概要

• エントリーDOI: 10.2210/pdb6b5v/pdb
• EMDBエントリー: 7058
• 分子名称: Transient receptor potential cation channel subfamily V member 5, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION (3 entities in total)
• 機能のキーワード: trpv5, econazole, transient receptor potential channel, cryo-em, membrane protein
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 333165.44

構造登録者

Hughes, T.E.T.,Lodowski, D.T.,Huynh, K.W.,Yazici, A.,del Rosario, J.,Kapoor, A.,Basak, S.,Samanta, A.,Chakrapani, S.,Zhou, Z.H.,Filizola, M.,Rohacs, T.,Han, S.,Moiseenkova-Bell, V.Y. (登録日: 2017-09-29, 公開日: 2017-12-27, 最終更新日: 2024-03-13)

• 主引用文献: Hughes, T.E.T.,Lodowski, D.T.,Huynh, K.W.,Yazici, A.,Del Rosario, J.,Kapoor, A.,Basak, S.,Samanta, A.,Han, X.,Chakrapani, S.,Zhou, Z.H.,Filizola, M.,Rohacs, T.,Han, S.,Moiseenkova-Bell, V.Y.; Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.; Nat. Struct. Mol. Biol., 25:53-60, 2018; PubMed: 29323279; DOI: 10.1038/s41594-017-0009-1

実験手法

ELECTRON MICROSCOPY (4.8 Å)