6B5A

Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide

6B5A の概要

• エントリーDOI: 10.2210/pdb6b5a/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2-(6-amino-9H-purin-9-yl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitor, benzenesulfonamide, purine, adenine, lyase, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29285.28

構造登録者

Lomelino, C.L.,McKenna, R.M. (登録日: 2017-09-28, 公開日: 2018-09-05, 最終更新日: 2023-10-04)

• 主引用文献: Nocentini, A.,Bua, S.,Lomelino, C.L.,McKenna, R.,Menicatti, M.,Bartolucci, G.,Tenci, B.,Di Cesare Mannelli, L.,Ghelardini, C.,Gratteri, P.,Supuran, C.T.; Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.; ACS Med Chem Lett, 8:1314-1319, 2017; PubMed: 29259754; DOI: 10.1021/acsmedchemlett.7b00399

実験手法

X-RAY DIFFRACTION (1.622 Å)