6B3E

Crystal structure of human CDK12/CyclinK in complex with an inhibitor

Summary for 6B3E

Entry DOI	10.2210/pdb6b3e/pdb
Descriptor	Cyclin-dependent kinase 12, Cyclin-K, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	inhibitor, complex, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: Q9NYV4 O75909
Total number of polymer chains	4
Total formula weight	138147.99
Authors	Ferguson, A.D. (deposition date: 2017-09-21, release date: 2017-12-27, Last modification date: 2023-10-04)
Primary citation	Johannes, J.W.,Denz, C.R.,Su, N.,Wu, A.,Impastato, A.C.,Mlynarski, S.,Varnes, J.G.,Prince, D.B.,Cidado, J.,Gao, N.,Haddrick, M.,Jones, N.H.,Li, S.,Li, X.,Liu, Y.,Nguyen, T.B.,O'Connell, N.,Rivers, E.,Robbins, D.W.,Tomlinson, R.,Yao, T.,Zhu, X.,Ferguson, A.D.,Lamb, M.L.,Manchester, J.I.,Guichard, S. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem, 13:231-235, 2018 Cited by PubMed: 29266803 DOI: 10.1002/cmdc.201700695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.06 Å)

Structure validation