6B33
Structure of RORgt in complex with a novel inverse agonist 3
Summary for 6B33
| Entry DOI | 10.2210/pdb6b33/pdb |
| Descriptor | Nuclear receptor ROR-gamma, (2R)-N~2~-(3-chloro-4-cyanophenyl)-N~4~-[3-(cyclopropylmethyl)-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]morpholine-2,4-dicarboxamide (3 entities in total) |
| Functional Keywords | complex, inverse agonist, nuclear hormone receptor, signaling protein-antagonist complex, signaling protein/antagonist |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 51902.75 |
| Authors | Skene, R.J.,Hoffman, I.,Snell, G. (deposition date: 2017-09-20, release date: 2018-11-21, Last modification date: 2024-03-13) |
| Primary citation | Sato, A.,Fukase, Y.,Kono, M.,Ochida, A.,Oda, T.,Sasaki, Y.,Ishii, N.,Tomata, Y.,Fukumoto, S.,Imai, Y.N.,Uga, K.,Shibata, A.,Yamasaki, M.,Nakagawa, H.,Shirasaki, M.,Skene, R.,Hoffman, I.,Sang, B.C.,Snell, G.,Shirai, J.,Yamamoto, S. Design and Synthesis of Conformationally Constrained ROR gamma t Inverse Agonists. Chemmedchem, 2019 Cited by PubMed: 31659845DOI: 10.1002/cmdc.201900416 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
Download full validation report
