6B33

Structure of RORgt in complex with a novel inverse agonist 3

6B33 の概要

• エントリーDOI: 10.2210/pdb6b33/pdb
• 分子名称: Nuclear receptor ROR-gamma, (2R)-N~2~-(3-chloro-4-cyanophenyl)-N~4~-[3-(cyclopropylmethyl)-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]morpholine-2,4-dicarboxamide (3 entities in total)
• 機能のキーワード: complex, inverse agonist, nuclear hormone receptor, signaling protein-antagonist complex, signaling protein/antagonist
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51902.75

構造登録者

Skene, R.J.,Hoffman, I.,Snell, G. (登録日: 2017-09-20, 公開日: 2018-11-21, 最終更新日: 2024-03-13)

• 主引用文献: Sato, A.,Fukase, Y.,Kono, M.,Ochida, A.,Oda, T.,Sasaki, Y.,Ishii, N.,Tomata, Y.,Fukumoto, S.,Imai, Y.N.,Uga, K.,Shibata, A.,Yamasaki, M.,Nakagawa, H.,Shirasaki, M.,Skene, R.,Hoffman, I.,Sang, B.C.,Snell, G.,Shirai, J.,Yamamoto, S.; Design and Synthesis of Conformationally Constrained ROR gamma t Inverse Agonists.; Chemmedchem, 2019; PubMed: 31659845; DOI: 10.1002/cmdc.201900416

実験手法

X-RAY DIFFRACTION (2.48 Å)