6B21

Crystal structure of AmtB from E. coli bound to TopFluor cardiolipin

Summary for 6B21

Entry DOI	10.2210/pdb6b21/pdb
Descriptor	Ammonia channel, [(2R,5R,11R,14S,24E)-14-[(acetyloxy)methyl]-8-{[5-(3,5-dimethyl-1H-pyrrol-2-yl-kappaN)-5-(3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)pentanoyl]oxy}-5,11-dihydroxy-2-{[(9E)-octadec-9-enoyl]oxy}-5,11,16-trioxo-4,6,10,12,15-pentaoxa-5lambda~5~,11lambda~5~-diphosphatritriacont-24-en-1-yl (9E)-octadec-9-enoatato](difluoro)boron (3 entities in total)
Functional Keywords	ammonia channel, amtb, cardiolipin, transporter, membrane protein
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	43855.21
Authors	Boone, C.D.,Laganowsky, A. (deposition date: 2017-09-19, release date: 2018-03-07, Last modification date: 2023-10-04)
Primary citation	Patrick, J.W.,Boone, C.D.,Liu, W.,Conover, G.M.,Liu, Y.,Cong, X.,Laganowsky, A. Allostery revealed within lipid binding events to membrane proteins. Proc. Natl. Acad. Sci. U.S.A., 115:2976-2981, 2018 Cited by PubMed: 29507234 DOI: 10.1073/pnas.1719813115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation