6B04

Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)

6B04 の概要

• エントリーDOI: 10.2210/pdb6b04/pdb
• 関連するPDBエントリー: 6B02 6B06 6B07
• 分子名称: Farnesyl diphosphate synthase, 2-(2,2-diphosphonoethyl)-1-methylpyridin-1-ium, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: juvenile hormone, farnesyl diphosphate synthase, inhibitor design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Choristoneura fumiferana (Spruce budworm moth)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 118858.68

構造登録者

Picard, M.-E.,Cusson, M.,Shi, R. (登録日: 2017-09-13, 公開日: 2017-12-13, 最終更新日: 2024-05-01)

• 主引用文献: Picard, M.E.,Nisole, A.,Beliveau, C.,Sen, S.,Barbar, A.,Shi, R.,Cusson, M.; Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.; Insect Biochem. Mol. Biol., 92:84-92, 2017; PubMed: 29183817; DOI: 10.1016/j.ibmb.2017.11.011

実験手法

X-RAY DIFFRACTION (1.83 Å)