6AYD
Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Summary for 6AYD
| Entry DOI | 10.2210/pdb6ayd/pdb |
| Descriptor | Serine/threonine-protein kinase pim-1, N-[6-(4-hydroxyphenyl)-2H-indazol-3-yl]cyclopropanecarboxamide (3 entities in total) |
| Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
| Total number of polymer chains | 1 |
| Total formula weight | 38355.47 |
| Authors | Shewchuk, L.M.,Henley, Z.A. (deposition date: 2017-09-08, release date: 2017-12-27, Last modification date: 2023-10-04) |
| Primary citation | Henley, Z.A.,Bax, B.D.,Inglesby, L.M.,Champigny, A.,Gaines, S.,Faulder, P.,Le, J.,Thomas, D.A.,Washio, Y.,Baldwin, I.R. From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome. ACS Med Chem Lett, 8:1093-1098, 2017 Cited by PubMed: 29057057DOI: 10.1021/acsmedchemlett.7b00296 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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