6AYB
Naegleria fowleri CYP51-ketoconazole complex
Summary for 6AYB
Entry DOI | 10.2210/pdb6ayb/pdb |
Related | 5TL8 6AY4 6AY6 |
Descriptor | CYP51, sterol 14alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | cyp51, sterol 14alpha-demethylase, oxidoreductase |
Biological source | Naegleria fowleri |
Total number of polymer chains | 1 |
Total formula weight | 55090.33 |
Authors | Debnath, A.,Calvet, C.M.,Jennings, G.,Zhou, W.,Aksenov, A.,Luth, M.,Abagyan, R.,Nes, W.D.,McKerrow, J.H.,Podust, L.M. (deposition date: 2017-09-08, release date: 2017-11-22, Last modification date: 2023-11-15) |
Primary citation | Debnath, A.,Calvet, C.M.,Jennings, G.,Zhou, W.,Aksenov, A.,Luth, M.R.,Abagyan, R.,Nes, W.D.,McKerrow, J.H.,Podust, L.M. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis, 11:e0006104-e0006104, 2017 Cited by PubMed: 29284029DOI: 10.1371/journal.pntd.0006104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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