6AUM
Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.
Summary for 6AUM
Entry DOI | 10.2210/pdb6aum/pdb |
Descriptor | Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | soluble epoxide hydrolase, urea inhibitors, neuropathic pain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 63349.65 |
Authors | Kodani, S.D.,Bahkta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B. (deposition date: 2017-09-01, release date: 2018-02-07, Last modification date: 2023-10-04) |
Primary citation | Kodani, S.D.,Bhakta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B.D. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg. Med. Chem. Lett., 28:762-768, 2018 Cited by PubMed: 29366648DOI: 10.1016/j.bmcl.2018.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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