6AUM

Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.

6AUM の概要

• エントリーDOI: 10.2210/pdb6aum/pdb
• 分子名称: Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: soluble epoxide hydrolase, urea inhibitors, neuropathic pain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63349.65

構造登録者

Kodani, S.D.,Bahkta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B. (登録日: 2017-09-01, 公開日: 2018-02-07, 最終更新日: 2023-10-04)

• 主引用文献: Kodani, S.D.,Bhakta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B.D.; Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.; Bioorg. Med. Chem. Lett., 28:762-768, 2018; PubMed: 29366648; DOI: 10.1016/j.bmcl.2018.01.003

実験手法

X-RAY DIFFRACTION (2.95 Å)