6AU2

Crystal structure of SETDB1 Tudor domain with aryl triazole fragments

6AU2 の概要

• エントリーDOI: 10.2210/pdb6au2/pdb
• 分子名称: Histone-lysine N-methyltransferase SETDB1, 1-methyl-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepine, BETA-MERCAPTOETHANOL, ... (7 entities in total)
• 機能のキーワード: setdb1 tudor, fragment hits, epigenetics, methyllysine reader, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26097.97

構造登録者

MADER, P.,Mendoza-Sanchez, R.,IQBAL, A.,DONG, A.,DOBROVETSKY, E.,CORLESS, V.B.,LIEW, S.K.,TEMPEL, W.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.,HOLOWNIA, A.,VEDADI, M.,BROWN, P.J.,SANTHAKUMAR, V.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (登録日: 2017-08-30, 公開日: 2017-10-11, 最終更新日: 2019-10-16)

• 主引用文献: Mader, P.,Mendoza-Sanchez, R.,Iqbal, A.,Dong, A.,Dobrovetsky, E.,Corless, V.B.,Liew, S.K.,Houliston, S.R.,De Freitas, R.F.,Smil, D.,Sena, C.C.D.,Kennedy, S.,Diaz, D.B.,Wu, H.,Dombrovski, L.,Allali-Hassani, A.,Min, J.,Schapira, M.,Vedadi, M.,Brown, P.J.,Santhakumar, V.,Yudin, A.K.,Arrowsmith, C.H.; Identification and characterization of the first fragment hits for SETDB1 Tudor domain.; Bioorg.Med.Chem., 27:3866-3878, 2019; PubMed: 31327677; DOI: 10.1016/j.bmc.2019.07.020

実験手法

X-RAY DIFFRACTION (1.63 Å)