6ATE

SRC kinase bound to covalent inhibitor

6ATE の概要

• エントリーDOI: 10.2210/pdb6ate/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide (3 entities in total)
• 機能のキーワード: kinase, phosphorylation, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33176.56

構造登録者

Gurbani, D.,Westover, K.D. (登録日: 2017-08-28, 公開日: 2019-02-27, 最終更新日: 2023-10-04)

• 主引用文献: Rao, S.,Gurbani, D.,Du, G.,Everley, R.A.,Browne, C.M.,Chaikuad, A.,Tan, L.,Schroder, M.,Gondi, S.,Ficarro, S.B.,Sim, T.,Kim, N.D.,Berberich, M.J.,Knapp, S.,Marto, J.A.,Westover, K.D.,Sorger, P.K.,Gray, N.S.; Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.; Cell Chem Biol, 26:818-829.e9, 2019; PubMed: 30982749; DOI: 10.1016/j.chembiol.2019.02.021

実験手法

X-RAY DIFFRACTION (2.402 Å)