6AQS

Crystal structure of Plasmodium falciparum purine nucleoside phosphorylase (V181D) mutant complexed with DADMe-ImmG and phosphate

6AQS の概要

• エントリーDOI: 10.2210/pdb6aqs/pdb
• 分子名称: Purine nucleoside phosphorylase, PHOSPHATE ION, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, ... (5 entities in total)
• 機能のキーワード: plasmodium falciparum, purine nucleoside phosphorylase (pnp), phosphorylase, pnp mutant, dadme-immg, transferase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27492.59

構造登録者

Harijan, R.K.,Ducati, R.G.,Namanja-Magliano, H.A.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (登録日: 2017-08-21, 公開日: 2018-02-14, 最終更新日: 2023-10-04)

• 主引用文献: Ducati, R.G.,Namanja-Magliano, H.A.,Harijan, R.K.,Fajardo, J.E.,Fiser, A.,Daily, J.P.,Schramm, V.L.; Genetic resistance to purine nucleoside phosphorylase inhibition in; Proc. Natl. Acad. Sci. U.S.A., 115:2114-2119, 2018; PubMed: 29440412; DOI: 10.1073/pnas.1525670115

実験手法

X-RAY DIFFRACTION (1.57 Å)