6AQO

Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)

Summary for 6AQO

Entry DOI	10.2210/pdb6aqo/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	purine salvage, trypanosoma brucei, acyclic nucleoside phosphonates, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Total number of polymer chains	6
Total formula weight	186626.22
Authors	Teran, D.,Gudday, L.W. (deposition date: 2017-08-21, release date: 2018-03-14, Last modification date: 2023-11-15)
Primary citation	Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567 DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation