6AQO

Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)

6AQO の概要

• エントリーDOI: 10.2210/pdb6aqo/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: purine salvage, trypanosoma brucei, acyclic nucleoside phosphonates, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 186626.22

構造登録者

Teran, D.,Gudday, L.W. (登録日: 2017-08-21, 公開日: 2018-03-14, 最終更新日: 2023-11-15)

• 主引用文献: Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A.; Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.; PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018; PubMed: 29481567; DOI: 10.1371/journal.pntd.0006301

実験手法

X-RAY DIFFRACTION (2.64 Å)