6APU
Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex with (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid
Summary for 6APU
Entry DOI | 10.2210/pdb6apu/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, SULFATE ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | purine salvage, acyclic nucleoside phosphonate, transferase |
Biological source | Trypanosoma brucei brucei |
Cellular location | Cytoplasm: Q07010 |
Total number of polymer chains | 2 |
Total formula weight | 49712.39 |
Authors | Teran, D.,Guddat, L. (deposition date: 2017-08-18, release date: 2018-03-14, Last modification date: 2023-10-04) |
Primary citation | Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.842 Å) |
Structure validation
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