6APU

Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex with (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid

Summary for 6APU

• Entry DOI: 10.2210/pdb6apu/pdb
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, SULFATE ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: purine salvage, acyclic nucleoside phosphonate, transferase
• Biological source: Trypanosoma brucei brucei
• Cellular location: Cytoplasm: Q07010
• Total number of polymer chains: 2
• Total formula weight: 49712.39

Authors

Teran, D.,Guddat, L. (deposition date: 2017-08-18, release date: 2018-03-14, Last modification date: 2023-10-04)

• Primary citation: Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A.; Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.; PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018; PubMed: 29481567; DOI: 10.1371/journal.pntd.0006301

Experimental method

X-RAY DIFFRACTION (1.842 Å)