6AOM
Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate
Summary for 6AOM
Entry DOI | 10.2210/pdb6aom/pdb |
Descriptor | Endoplasmin, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate, ... (6 entities in total) |
Functional Keywords | grp94, hsp90, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Canis lupus familiaris (Dog) More |
Cellular location | Endoplasmic reticulum lumen: P41148 |
Total number of polymer chains | 2 |
Total formula weight | 58262.92 |
Authors | Lieberman, R.L.,Huard, D.J.E. (deposition date: 2017-08-16, release date: 2017-10-11, Last modification date: 2023-10-04) |
Primary citation | Crowley, V.M.,Huard, D.J.E.,Lieberman, R.L.,Blagg, B.S.J. Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer. Chemistry, 23:15775-15782, 2017 Cited by PubMed: 28857290DOI: 10.1002/chem.201703398 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
Download full validation report