6AOH

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)

Summary for 6AOH

• Entry DOI: 10.2210/pdb6aoh/pdb
• Related: 6AOG
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: toxoplasma gondii, pyrimethamine, dhfr, oxidoreductase
• Biological source: Toxoplasma gondii; More
• Total number of polymer chains: 2
• Total formula weight: 132247.63

Authors

Thomas, S.B.,Li, Y.,Chen, Z.,Lu, H. (deposition date: 2017-08-16, release date: 2018-08-22, Last modification date: 2023-10-04)

• Primary citation: Thomas, S.B.,Hopper, A.; Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.5 Å)