6AOG
Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)
Summary for 6AOG
Entry DOI | 10.2210/pdb6aog/pdb |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | toxoplasma gondii, pyrimethamine, dhfr, oxidoreductase |
Biological source | Toxoplasma gondii More |
Total number of polymer chains | 2 |
Total formula weight | 131988.19 |
Authors | Thomas, S.B.,Li, Y.,Chen, Z.,Lu, H. (deposition date: 2017-08-16, release date: 2018-08-22, Last modification date: 2023-10-04) |
Primary citation | Thomas, S.B.,Hopper, A. Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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