6AOG

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)

6AOG の概要

• エントリーDOI: 10.2210/pdb6aog/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: toxoplasma gondii, pyrimethamine, dhfr, oxidoreductase
• 由来する生物種: Toxoplasma gondii; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131988.19

構造登録者

Thomas, S.B.,Li, Y.,Chen, Z.,Lu, H. (登録日: 2017-08-16, 公開日: 2018-08-22, 最終更新日: 2023-10-04)

• 主引用文献: Thomas, S.B.,Hopper, A.; Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis; To Be Published,

実験手法

X-RAY DIFFRACTION (3.2 Å)