6AOC

Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase

6AOC の概要

• エントリーDOI: 10.2210/pdb6aoc/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: hiv-1, transferase - transferase inhibitor complex, transferase / transferase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 234444.14

構造登録者

Kirby, K.A.,Sarafianos, S.G. (登録日: 2017-08-15, 公開日: 2018-08-08, 最終更新日: 2023-10-04)

• 主引用文献: Kankanala, J.,Kirby, K.A.,Huber, A.D.,Casey, M.C.,Wilson, D.J.,Sarafianos, S.G.,Wang, Z.; Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.; Eur J Med Chem, 141:149-161, 2017; PubMed: 29031062; DOI: 10.1016/j.ejmech.2017.09.054

実験手法

X-RAY DIFFRACTION (1.8 Å)