6AN1

Crystal structure of the complex between PPARgamma LBD and the ligand AM-879

6AN1 の概要

• エントリーDOI: 10.2210/pdb6an1/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 4-({2-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]phenoxy}methyl)benzoic acid (3 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65629.87

構造登録者

Veras, H.,Figueira, A.C.,le Maire, A. (登録日: 2017-08-11, 公開日: 2018-02-14, 最終更新日: 2024-03-13)

• 主引用文献: Ribeiro Filho, H.V.,Bernardi Videira, N.,Bridi, A.V.,Tittanegro, T.H.,Helena Batista, F.A.,de Carvalho Pereira, J.G.,de Oliveira, P.S.L.,Bajgelman, M.C.,Le Maire, A.,Figueira, A.C.M.; Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties.; Front Endocrinol (Lausanne), 9:11-11, 2018; PubMed: 29449830; DOI: 10.3389/fendo.2018.00011

実験手法

X-RAY DIFFRACTION (2.687 Å)