6ALJ

ALDH1A2 liganded with NAD and compound WIN18,446

Summary for 6ALJ

Entry DOI	10.2210/pdb6alj/pdb
Related	6B5G 6B5H 6B5I
Descriptor	Aldehyde dehydrogenase 1A2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide), ... (4 entities in total)
Functional Keywords	retinoic acid signaling, male contraception, drug discovery, drug development, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	220800.55
Authors	Chen, Y.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-08-08, release date: 2018-01-10, Last modification date: 2023-10-04)
Primary citation	Chen, Y.,Zhu, J.Y.,Hong, K.H.,Mikles, D.C.,Georg, G.I.,Goldstein, A.S.,Amory, J.K.,Schonbrunn, E. Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem. Biol., 13:582-590, 2018 Cited by PubMed: 29240402 DOI: 10.1021/acschembio.7b00685 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation