6AKW

Crystal structure of RNA dioxygenase bound with an inhibitor

Summary for 6AKW

Entry DOI	10.2210/pdb6akw/pdb
Descriptor	Alpha-ketoglutarate-dependent dioxygenase FTO, 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid, ... (4 entities in total)
Functional Keywords	rna demethylase, inhibitor, oxidation, rna binding protein, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	57048.99
Authors	Yang, C.-G.,Huang, Y.,Gan, J. (deposition date: 2018-09-04, release date: 2019-05-29, Last modification date: 2023-11-22)
Primary citation	Huang, Y.,Su, R.,Sheng, Y.,Dong, L.,Dong, Z.,Xu, H.,Ni, T.,Zhang, Z.S.,Zhang, T.,Li, C.,Han, L.,Zhu, Z.,Lian, F.,Wei, J.,Deng, Q.,Wang, Y.,Wunderlich, M.,Gao, Z.,Pan, G.,Zhong, D.,Zhou, H.,Zhang, N.,Gan, J.,Jiang, H.,Mulloy, J.C.,Qian, Z.,Chen, J.,Yang, C.G. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell, 35:677-691.e10, 2019 Cited by PubMed: 30991027 DOI: 10.1016/j.ccell.2019.03.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation