6AKR

Crystal structure of the PDE4D catalytic domain in complex with osthole

Summary for 6AKR

• Entry DOI: 10.2210/pdb6akr/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, ... (4 entities in total)
• Functional Keywords: phosphodiesterase 4d, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 168733.38

Authors

Wang, S.,Huo, Y.W.,Xie, Y. (deposition date: 2018-09-03, release date: 2020-02-12, Last modification date: 2023-11-22)

• Primary citation: Wang, S.,Xie, Y.,Huo, Y.W.,Li, Y.,Abel, P.W.,Jiang, H.,Zou, X.,Jiao, H.Z.,Kuang, X.,Wolff, D.W.,Huang, Y.G.,Casale, T.B.,Panettieri Jr., R.A.,Wei, T.,Cao, Z.,Tu, Y.; Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.; Sci.Signal., 13:-, 2020; PubMed: 33234690; DOI: 10.1126/scisignal.aax0273

Experimental method

X-RAY DIFFRACTION (2.326 Å)