6AK2

Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018

Summary for 6AK2

Entry DOI	10.2210/pdb6ak2/pdb
Descriptor	Syntenin-1, peptide inhibitor KSL-128018 (3 entities in total)
Functional Keywords	signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	4
Total formula weight	19482.44
Authors	Jin, Z.Y.,Park, J.H.,Yun, J.H.,Haugaard-Kedstrom, L.M.,Lee, W.T. (deposition date: 2018-08-29, release date: 2019-09-04, Last modification date: 2023-11-22)
Primary citation	Haugaard-Kedstrom, L.M.,Clemmensen, L.S.,Sereikaite, V.,Jin, Z.,Fernandes, E.F.A.,Wind, B.,Abalde-Gil, F.,Daberger, J.,Vistrup-Parry, M.,Aguilar-Morante, D.,Leblanc, R.,Egea-Jimenez, A.L.,Albrigtsen, M.,Jensen, K.E.,Jensen, T.M.T.,Ivarsson, Y.,Vincentelli, R.,Hamerlik, P.,Andersen, J.H.,Zimmermann, P.,Lee, W.,Stromgaard, K. A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem., 64:1423-1434, 2021 Cited by PubMed: 33502198 DOI: 10.1021/acs.jmedchem.0c00382 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.868 Å)

Structure validation