6AHS

Mouse Kallikrein 7 in complex with imidazolinylindole derivative

Summary for 6AHS

Entry DOI	10.2210/pdb6ahs/pdb
Descriptor	Kallikrein-7, 1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	protease, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	25218.27
Authors	Sugawara, H. (deposition date: 2018-08-20, release date: 2019-01-02, Last modification date: 2023-11-22)
Primary citation	Murafuji, H.,Muto, T.,Goto, M.,Imajo, S.,Sugawara, H.,Oyama, Y.,Minamitsuji, Y.,Miyazaki, S.,Murai, K.,Fujioka, H. Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors. Bioorg. Med. Chem. Lett., 29:334-338, 2019 Cited by PubMed: 30522951 DOI: 10.1016/j.bmcl.2018.11.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation