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6AGT

Crystal structure of PfKRS complexed with chromone inhibitor

6AGT の概要
エントリーDOI10.2210/pdb6agt/pdb
分子名称Lysine--tRNA ligase, N-(cyclohexylmethyl)-4-oxo-4H-1-benzopyran-2-carboxamide, COBALT (II) ION, ... (7 entities in total)
機能のキーワードkrs, chromone inhibitor, aminoacylation, atp binding protein, ligase-inhibitor complex, ligase/inhibitor
由来する生物種Plasmodium falciparum
タンパク質・核酸の鎖数4
化学式量合計237290.78
構造登録者
Yogavel, M.,Sharma, A.,Sharma, A.,Baragana, B.,Walpole, C. (登録日: 2018-08-14, 公開日: 2019-03-13, 最終更新日: 2023-11-22)
主引用文献Baragana, B.,Forte, B.,Choi, R.,Nakazawa Hewitt, S.,Bueren-Calabuig, J.A.,Pisco, J.P.,Peet, C.,Dranow, D.M.,Robinson, D.A.,Jansen, C.,Norcross, N.R.,Vinayak, S.,Anderson, M.,Brooks, C.F.,Cooper, C.A.,Damerow, S.,Delves, M.,Dowers, K.,Duffy, J.,Edwards, T.E.,Hallyburton, I.,Horst, B.G.,Hulverson, M.A.,Ferguson, L.,Jimenez-Diaz, M.B.,Jumani, R.S.,Lorimer, D.D.,Love, M.S.,Maher, S.,Matthews, H.,McNamara, C.W.,Miller, P.,O'Neill, S.,Ojo, K.K.,Osuna-Cabello, M.,Pinto, E.,Post, J.,Riley, J.,Rottmann, M.,Sanz, L.M.,Scullion, P.,Sharma, A.,Shepherd, S.M.,Shishikura, Y.,Simeons, F.R.C.,Stebbins, E.E.,Stojanovski, L.,Straschil, U.,Tamaki, F.K.,Tamjar, J.,Torrie, L.S.,Vantaux, A.,Witkowski, B.,Wittlin, S.,Yogavel, M.,Zuccotto, F.,Angulo-Barturen, I.,Sinden, R.,Baum, J.,Gamo, F.J.,Maser, P.,Kyle, D.E.,Winzeler, E.A.,Myler, P.J.,Wyatt, P.G.,Floyd, D.,Matthews, D.,Sharma, A.,Striepen, B.,Huston, C.D.,Gray, D.W.,Fairlamb, A.H.,Pisliakov, A.V.,Walpole, C.,Read, K.D.,Van Voorhis, W.C.,Gilbert, I.H.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 116:7015-7020, 2019
Cited by
PubMed: 30894487
DOI: 10.1073/pnas.1814685116
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.953 Å)
構造検証レポート
Validation report summary of 6agt
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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