6AFR

Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol

Summary for 6AFR

Entry DOI	10.2210/pdb6afr/pdb
Descriptor	Bromodomain-containing protein 4, 5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol (3 entities in total)
Functional Keywords	brd4, epigenetic, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15342.62
Authors	Xing, J.,Zhang, R.K.,Zheng, M.Y.,Luo, C.,Jiang, X.R. (deposition date: 2018-08-08, release date: 2018-12-12, Last modification date: 2024-03-27)
Primary citation	Xing, J.,Zhang, R.,Jiang, X.,Hu, T.,Wang, X.,Qiao, G.,Wang, J.,Yang, F.,Luo, X.,Chen, K.,Shen, J.,Luo, C.,Jiang, H.,Zheng, M. Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors Eur J Med Chem, 163:281-294, 2018 Cited by PubMed: 30529546 DOI: 10.1016/j.ejmech.2018.11.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.998 Å)

Structure validation