6AFR

Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol

6AFR の概要

• エントリーDOI: 10.2210/pdb6afr/pdb
• 分子名称: Bromodomain-containing protein 4, 5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol (3 entities in total)
• 機能のキーワード: brd4, epigenetic, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15342.62

構造登録者

Xing, J.,Zhang, R.K.,Zheng, M.Y.,Luo, C.,Jiang, X.R. (登録日: 2018-08-08, 公開日: 2018-12-12, 最終更新日: 2024-03-27)

• 主引用文献: Xing, J.,Zhang, R.,Jiang, X.,Hu, T.,Wang, X.,Qiao, G.,Wang, J.,Yang, F.,Luo, X.,Chen, K.,Shen, J.,Luo, C.,Jiang, H.,Zheng, M.; Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors; Eur J Med Chem, 163:281-294, 2018; PubMed: 30529546; DOI: 10.1016/j.ejmech.2018.11.018

実験手法

X-RAY DIFFRACTION (1.998 Å)