6AEK
Crystal structure of ENPP1 in complex with pApG
Summary for 6AEK
| Entry DOI | 10.2210/pdb6aek/pdb |
| Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
| Functional Keywords | enzyme, phoshodiesterase, cgamp, cgas-sting, cyclic gmp-amp, immunosuppressant |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 87532.79 |
| Authors | Kato, K.,Nishimasu, H.,Hirano, S.,Hirano, H.,Ishitani, R.,Nureki, O. (deposition date: 2018-08-05, release date: 2019-03-06, Last modification date: 2023-11-22) |
| Primary citation | Kato, K.,Nishimasu, H.,Oikawa, D.,Hirano, S.,Hirano, H.,Kasuya, G.,Ishitani, R.,Tokunaga, F.,Nureki, O. Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun, 9:4424-4424, 2018 Cited by PubMed: 30356045DOI: 10.1038/s41467-018-06922-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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