6ADQ

Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis

6ADQ の概要

• エントリーDOI: 10.2210/pdb6adq/pdb
• EMDBエントリー: 9610
• 分子名称: Cytochrome c oxidase subunit 2, Ubiquinol-cytochrome c reductase cytochrome b subunit, Cytochrome bc1 complex cytochrome c subunit, ... (23 entities in total)
• 機能のキーワード: respiratory, supercomplex, sod, mycobacterium, etc, lipoprotein, electron transport
• 由来する生物種: Mycobacterium smegmatis MC2 51; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 769566.28

構造登録者

Gong, H.R.,Xu, A.,Gao, R.G.,Ji, W.X.,Wang, S.H.,Wang, Q.,Li, J.,Rao, Z.H. (登録日: 2018-08-01, 公開日: 2018-11-14, 最終更新日: 2025-09-17)

主引用文献

Gong, H.,Li, J.,Xu, A.,Tang, Y.,Ji, W.,Gao, R.,Wang, S.,Yu, L.,Tian, C.,Li, J.,Yen, H.Y.,Man Lam, S.,Shui, G.,Yang, X.,Sun, Y.,Li, X.,Jia, M.,Yang, C.,Jiang, B.,Lou, Z.,Robinson, C.V.,Wong, L.L.,Guddat, L.W.,Sun, F.,Wang, Q.,Rao, Z.
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.
Science, 362:-, 2018

PubMed Abstract: We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis.

PubMed: 30361386
DOI: 10.1126/science.aat8923

実験手法

ELECTRON MICROSCOPY (3.5 Å)