Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a

Summary for 6A95

EMDB information6997
DescriptorSodium channel protein PaFPC1, Mu-diguetoxin-Dc1a, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordscomplex, sodium channel, toxin, membrane protein, membrane protein-toxin complex, membrane protein/toxin
Biological sourcePeriplaneta americana (American cockroach)
Total number of polymer chains2
Total molecular weight192268.58
Shen, H.Z.,li, Z.Q.,Jiang, Y.,Pan, X.J.,Wu, J.P.,Cristofori-Armstrong, B.,Smith, J.J.,Chin, Y.K.Y.,Lei, J.L.,Zhou, Q.,King, G.F.,Yan, N. (deposition date: 2018-07-11, release date: 2018-08-08, Last modification date: 2018-12-26)
Primary citation
Shen, H.,Li, Z.,Jiang, Y.,Pan, X.,Wu, J.,Cristofori-Armstrong, B.,Smith, J.J.,Chin, Y.K.Y.,Lei, J.,Zhou, Q.,King, G.F.,Yan, N.
Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362:-, 2018
PubMed: 30049784 (PDB entries with the same primary citation)
DOI: 10.1126/science.aau2596
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers4 0.4% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures