6A94

Crystal structure of 5-HT2AR in complex with zotepine

Summary for 6A94

Descriptor5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, CHOLESTEROL, ... (7 entities in total)
Functional Keywordsreceptor, membrane protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight86215.78
Authors
Primary citation
Kimura, T.K.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T.
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepin
Nat.Struct.Mol.Biol., 26:121-128, 2019
DOI: 10.1038/s41594-018-0180-z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26940 0.6% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 6a94
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Molmil generated image of 6a94
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Molmil generated image of 6a94
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6a94.pdb1.gz [125.46 KB])
Coordinate files for Biological unit (6a94.pdb2.gz [122.64 KB])