6A79

Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B

6A79 の概要

• エントリーDOI: 10.2210/pdb6a79/pdb
• 分子名称: Roundabout homolog 1, Light chain region of the anti-human Robo1 antibody B5209B scFv, Heavy chain of the anti-human Robo1 antibody B5209B scFv, ... (5 entities in total)
• 機能のキーワード: hepatocellular carcinoma antigen, angiogenesis, immune system, antibody drug, single-chain variable fragment
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 72440.59

構造登録者

Mizohata, E.,Nakayama, T.,Kado, Y.,Yokota, Y.,Inoue, T. (登録日: 2018-07-02, 公開日: 2019-01-30, 最終更新日: 2019-03-20)

• 主引用文献: Yamashita, T.,Mizohata, E.,Nagatoishi, S.,Watanabe, T.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Nakayama, T.,Kado, Y.,Yokota, Y.,Matsumura, H.,Kawamura, T.,Kodama, T.,Hamakubo, T.,Inoue, T.,Fujitani, H.,Tsumoto, K.; Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface.; Structure, 27:519-, 2019; PubMed: 30595454; DOI: 10.1016/j.str.2018.11.002

実験手法

X-RAY DIFFRACTION (2.31 Å)