6A6K
Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000
Summary for 6A6K
Entry DOI | 10.2210/pdb6a6k/pdb |
Descriptor | Estrogen-related receptor gamma, 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol (3 entities in total) |
Functional Keywords | sodium iodide symporter (nis), anaplastic thyroid cancer, estrogen-related receptor gamma, radioiodine therapy, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 82395.35 |
Authors | |
Primary citation | Kim, J.,Song, J.,Ji, H.D.,Yoo, E.K.,Lee, J.E.,Lee, S.B.,Oh, J.M.,Lee, S.,Hwang, J.S.,Yoon, H.,Kim, D.S.,Lee, S.J.,Jeong, M.,Lee, S.,Kim, K.H.,Choi, H.S.,Lee, S.W.,Park, K.G.,Lee, I.K.,Kim, S.H.,Hwang, H.,Jeon, Y.H.,Chin, J.,Cho, S.J. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J. Med. Chem., 62:1837-1858, 2019 Cited by PubMed: 30657313DOI: 10.1021/acs.jmedchem.8b01296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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