The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of streptoseomycin

Summary for 6A5G

Descriptor[4+2] and [4+6] cyclase StmD (2 entities in total)
Functional Keywords[4+2] and [4+6] cyclase, streptoseomycin, biosynthesis, biosynthetic protein
Biological sourceStreptomyces seoulensis
Total number of polymer chains4
Total molecular weight72647.81
Zhang, B.,Ge, H.M. (deposition date: 2018-06-23, release date: 2019-02-06, Last modification date: 2019-04-17)
Primary citation
Zhang, B.,Wang, K.B.,Wang, W.,Wang, X.,Liu, F.,Zhu, J.,Shi, J.,Li, L.Y.,Han, H.,Xu, K.,Qiao, H.Y.,Zhang, X.,Jiao, R.H.,Houk, K.N.,Liang, Y.,Tan, R.X.,Ge, H.M.
Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568:122-126, 2019
PubMed: 30867595 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-1021-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24630 3.6% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution