6A3V

Complex structure of human 4-1BB and 4-1BBL

Summary for 6A3V

DescriptorTumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE (3 entities in total)
Functional Keywordscomplex structure, agonist monoclonal antibody, cross-linking, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains24
Total molecular weight471146.77
Authors
Li, Y.,Zhang, C.,Chai, Y.,Qi, J.,Tien, P.,Gao, S.,Gao, G.F. (deposition date: 2018-06-17, release date: 2018-10-10, Last modification date: 2019-04-24)
Primary citation
Li, Y.,Tan, S.,Zhang, C.,Chai, Y.,He, M.,Zhang, C.W.,Wang, Q.,Tong, Z.,Liu, K.,Lei, Y.,Liu, W.J.,Liu, Y.,Tian, Z.,Cao, X.,Yan, J.,Qi, J.,Tien, P.,Gao, S.,Gao, G.F.
Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25:909-920.e4, 2018
PubMed: 30355497 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2018.09.073
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.391 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.293100 3.5% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report