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6A2P

Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP

Summary for 6A2P
Entry DOI10.2210/pdb6a2p/pdb
DescriptorBifunctional dihydrofolate reductase-thymidylate synthase, 5,5'-[propane-1,3-diylbis(oxy-4,1-phenylene)]bis(6-ethylpyrimidine-2,4-diamine), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordsrossmann fold, dual-binding inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourcePlasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains2
Total formula weight146177.23
Authors
Chitnumsub, P.,Jaruwat, A.,Tarnchampoo, B.,Yuthavong, Y. (deposition date: 2018-06-12, release date: 2019-04-24, Last modification date: 2023-11-22)
Primary citationTarnchompoo, B.,Chitnumsub, P.,Jaruwat, A.,Shaw, P.J.,Vanichtanankul, J.,Poen, S.,Rattanajak, R.,Wongsombat, C.,Tonsomboon, A.,Decharuangsilp, S.,Anukunwithaya, T.,Arwon, U.,Kamchonwongpaisan, S.,Yuthavong, Y.
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett, 9:1235-1240, 2018
Cited by
PubMed: 30613332
DOI: 10.1021/acsmedchemlett.8b00389
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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