6A22

Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.

Summary for 6A22

Entry DOI	10.2210/pdb6a22/pdb
Descriptor	Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, ... (4 entities in total)
Functional Keywords	ternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, nuclear protein/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	131291.65
Authors	Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Adachi, T. (deposition date: 2018-06-08, release date: 2018-12-12, Last modification date: 2023-11-22)
Primary citation	Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Maeda, K.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Crowe, P.,Tao, H.,Thacher, S.,Adachi, T. Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Sci Rep, 8:17374-17374, 2018 Cited by PubMed: 30478402 DOI: 10.1038/s41598-018-35783-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation