6A22

Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.

6A22 の概要

• エントリーDOI: 10.2210/pdb6a22/pdb
• 分子名称: Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, ... (4 entities in total)
• 機能のキーワード: ternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, nuclear protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 131291.65

構造登録者

Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Adachi, T. (登録日: 2018-06-08, 公開日: 2018-12-12, 最終更新日: 2023-11-22)

• 主引用文献: Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Maeda, K.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Crowe, P.,Tao, H.,Thacher, S.,Adachi, T.; Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction; Sci Rep, 8:17374-17374, 2018; PubMed: 30478402; DOI: 10.1038/s41598-018-35783-9

実験手法

X-RAY DIFFRACTION (2.55 Å)