6A1G

Crystal structure of human DYRK1A in complex with compound 32

6A1G の概要

• エントリーDOI: 10.2210/pdb6a1g/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 5,5-dimethyl-8-[1-(piperidin-4-yl)ethenyl]-5,6-dihydrobenzo[h]quinazolin-4-amine (3 entities in total)
• 機能のキーワード: dyrk1a, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84477.76

構造登録者

Baba, D.,Hanzawa, H. (登録日: 2018-06-07, 公開日: 2018-10-03, 最終更新日: 2023-11-22)

• 主引用文献: Fukuda, T.,Ishiyama, T.,Katagiri, T.,Ueda, K.,Muramatsu, S.,Hashimoto, M.,Aki, A.,Baba, D.,Watanabe, K.,Tanaka, N.; Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives.; Bioorg. Med. Chem. Lett., 28:3333-3337, 2018; PubMed: 30217414; DOI: 10.1016/j.bmcl.2018.09.010

実験手法

X-RAY DIFFRACTION (2.15 Å)