6ZJ1
Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with tetrasaccharide N-glycan fragment and hexatungstotellurate(VI) TEW
This is a non-PDB format compatible entry.
Summary for 6ZJ1
Entry DOI | 10.2210/pdb6zj1/pdb |
Descriptor | Glycoprotein endo-alpha-1,2-mannosidase, alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | golgi, hydrolase, mannosidase, retaining |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 48716.27 |
Authors | Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. (deposition date: 2020-06-27, release date: 2020-12-02, Last modification date: 2024-01-31) |
Primary citation | Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117:29595-29601, 2020 Cited by PubMed: 33154157DOI: 10.1073/pnas.2013620117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.957 Å) |
Structure validation
Download full validation report