6ZDV
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 5d
Summary for 6ZDV
Entry DOI | 10.2210/pdb6zdv/pdb |
Related | 6ZRD |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, [2-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate, SODIUM ION, ... (8 entities in total) |
Functional Keywords | g protein-coupled receptor, membrane protein, receptor, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 54204.65 |
Authors | Verdon, G.,Jespers, W.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.,Mason, J.,Aqvist, J.,Cooke, R.,Sotelo, E.,Gutierrez-de-Teran, H. (deposition date: 2020-06-15, release date: 2020-09-16, Last modification date: 2024-01-24) |
Primary citation | Jespers, W.,Verdon, G.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-Mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.S.,Mason, J.S.,Aqvist, J.,Cooke, R.M.,Sotelo, E.,Gutierrez-de-Teran, H. X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists. Angew.Chem.Int.Ed.Engl., 59:16536-16543, 2020 Cited by PubMed: 32542862DOI: 10.1002/anie.202003788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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