6ZA4

M. tuberculosis salicylate synthase MbtI in complex with 5-(3-cyanophenyl)furan-2-carboxylate

Summary for 6ZA4

Entry DOI	10.2210/pdb6za4/pdb
Descriptor	Salicylate synthase, 5-(3-cyanophenyl)furan-2-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	salicylate, isochorismate, chorismate, mycobactins, lyase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	196913.95
Authors	Mori, M.,Villa, S.,Meneghetti, F.,Bellinzoni, M. (deposition date: 2020-06-04, release date: 2020-07-01, Last modification date: 2024-01-24)
Primary citation	Mori, M.,Stelitano, G.,Gelain, A.,Pini, E.,Chiarelli, L.R.,Sammartino, J.C.,Poli, G.,Tuccinardi, T.,Beretta, G.,Porta, A.,Bellinzoni, M.,Villa, S.,Meneghetti, F. Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63:7066-7080, 2020 Cited by PubMed: 32530281 DOI: 10.1021/acs.jmedchem.0c00373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.092 Å)

Structure validation