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6Z84

CK2 alpha bound to chemical probe SGC-CK2-1 derivative

This is a non-PDB format compatible entry.
Summary for 6Z84
Entry DOI10.2210/pdb6z84/pdb
DescriptorCasein kinase II subunit alpha, SULFATE ION, ~{N}-[1-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]indol-6-yl]ethanamide, ... (4 entities in total)
Functional Keywordskinase, inhibitor, chemical probe, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight82551.50
Authors
Kraemer, A.,Wells, C.,Drewry, D.H.,Pickett, J.E.,Axtman, A.D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-06-02, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citationWells, C.I.,Drewry, D.H.,Pickett, J.E.,Tjaden, A.,Kramer, A.,Muller, S.,Gyenis, L.,Menyhart, D.,Litchfield, D.W.,Knapp, S.,Axtman, A.D.
Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Cell Chem Biol, 28:546-558.e10, 2021
Cited by
PubMed: 33484635
DOI: 10.1016/j.chembiol.2020.12.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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