Summary for 6Z7L
Entry DOI | 10.2210/pdb6z7l/pdb |
Descriptor | Bromodomain-containing protein 4, (3~{R},4~{R})-~{N}-cyclohexyl-4-[[5-(furan-2-yl)-3-methyl-2-oxidanylidene-1~{H}-1,7-naphthyridin-8-yl]amino]-1-methyl-piperidine-3-carboxamide (3 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15562.95 |
Authors | Chung, C. (deposition date: 2020-05-31, release date: 2020-07-29, Last modification date: 2024-05-01) |
Primary citation | Watson, R.J.,Bamborough, P.,Barnett, H.,Chung, C.W.,Davis, R.,Gordon, L.,Grandi, P.,Petretich, M.,Phillipou, A.,Prinjha, R.K.,Rioja, I.,Soden, P.,Werner, T.,Demont, E.H. GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. J.Med.Chem., 63:9045-9069, 2020 Cited by PubMed: 32691589DOI: 10.1021/acs.jmedchem.0c00614 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.624 Å) |
Structure validation
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